Neuropediatrics. Involvement in research to advance the understanding of this disease and partnership with international collaborators and family organizations are also important. West Afr J Med. CAS  Duke University Children Health Center, 2301 Erwin Rd., Durham, NC, 27710, USA, Melanie Masoud BA, Lyndsey Prange CPNP, Arsen Hunanyan PhD & Mohamad A. Mikati MD, Cure AHC, Inc., 545 Irina Drive, Rolesville, NC, 27571, USA, You can also search for this author in Alternating hemiplegia in childhood: a report of eight patients with complicated migraine beginning in infancy. A case of alternating hemiplegia of childhood with cerebellar atrophy. A broad differential diagnosis is necessary when considering this condition. Part of Springer Nature. This article does not contain any studies with human or animal subjects performed by any of the authors. 2000;31(6):307–9. •• Rosewich H et al. Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder characterized by recurrent paroxysmal hemiplegic attacks that affect one or the other side of the body. J Neurosci. The contributions of all of the above have been invaluable in pushing the understanding and care of AHC to its current level as presented in this article. An example of such an approach is that of The Duke AHC and Related Disorders Multi-Disciplinary Clinic and Program, which, in partnership with the Cure AHC Foundation, has developed and applied this approach to patients seen since early 2013. Orphanet J Rare Dis. Mikati MA et al. Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disease caused by heterozygous de novo missense mutations in the ATP1A3 gene that … Evidence of a non-progressive course of alternating hemiplegia of childhood: study of a large cohort of children and adults. The diagnosis and treatment of patients with Alternating Hemiplegia of Childhood (AHC) and related disorders should be provided by a multidisciplinary team experienced with the spectrum of presentations of this disease, with its related disorders, with its complex and fluctuating manifestations, and with cutting edge advances occurring in the field. ATP1A3 mutation in a Chinese girl with alternating hemiplegia of childhood--Potential target of treatment? PLoS ONE. Google Scholar. Alternating hemiplegia in a child misdiagnosed as intractable epilepsy successfully treated with aripiprazole: a case report. PubMed Central  2015;37(9):907–10. Paciorkowski AR et al. Haffejee S, Santosh PJ. 2016;11(1):55. Successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood. What is AHC? Heimer G et al. 2014;344(1–2):37–42. A case of alternating hemiplegia of childhood with cerebellar atrophy. Google Scholar. 2000;15(2):128–30. 2011;519(2):376–404. heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study. Developmental Medicine and Child Neurology, in press. MELAS syndrome: characteristic migrainous and epileptic features and maternal transmission. Roubergue A et al. https://doi.org/10.1007/s11940-017-0444-7, DOI: https://doi.org/10.1007/s11940-017-0444-7, Over 10 million scientific documents at your fingertips, Not logged in Lancet Neurol. 2011;31(23):8689–96. Diagnosis and Treatment of Alternating Hemiplegia of Childhood. Intermediate phenotypes of ATP1A3 mutations: phenotype-genotype correlations. Attacks may range from mild weakness to full paralysis and may last for minutes, hours or even days. 50 percent of children with ATP1A3 mutations, alternating hemiplegia is a neurological! The paralysis alternates from one side of the disorder is characterized by episodes! 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alternating hemiplegia of childhood treatment

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